![]() Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube. ![]() © 2017 American Society for Veterinary Clinical Pathology. Although lactate was increased in the CPDA samples it was not high enough to decrease pH and therefore may not have been high enough to cause morphologic lesions and loss of PLT viability. This may be associated with the higher, more neutral pH as well as an increase in glucose available for metabolism. Platelet aggregometry results suggest that CPDA is superior to ACD for maintaining PLT viability following whole blood collection. Potassium, oxygen, and carbon dioxide concentrations were significantly higher in ACD compared to CPDA at collection. Lactate concentration was higher following one hour in either anticoagulant. Blood glucose, pH, bicarbonate, sodium, and lactate concentrations were significantly higher in CPDA compared to ACD. Aggregometry mean amplitudes were significantly higher in CPDA compared to ACD. Platelet count, pH, and concentrations of glucose, lactate, carbon dioxide, oxygen, bicarbonate, sodium, potassium, and chloride were measured within 10 minutes of collection and then again one hour later at which time PLT aggregometry was performed to assess PLT function. Whole blood from 6 healthy adult Thoroughbred horses was collected into citrate-phosphate-dextrose-adenine (CPDA) or acid-citrate-dextrose (ACD). ![]() The purpose of the study was to compare viability of PLTs collected in whole blood into 2 different anticoagulants. Comparison of equine platelet function and survival in whole blood collected in acid-citrate-dextrose solution or citrate-phosphate-dextrose-adenine solution.īozorgmanesh, Rana Sutton-Burges, Julie W Tablin, FernĮquine whole blood collection and storage methods have been evaluated to assess red blood cell viability however, platelet (PLT) viability has not been comprehensively assessed. ![]()
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